| Sisymbrium versicolor (Brandegee) O.E. Schulz, 1924 |
| Sisymbrium virletii E. Fourn., 1865 |
| Sisymbrium walteri Elliott, 1822 |
| Sisymbrium wootonii B.L. Rob., 1900 |
| Sophia Adans., 1763 |
| Sophia adenophora Wooton & Standl., 1913 |
| Sophia andrenarum Cockerell, 1901 |
| Sophia andrenarum var. osmiarum Cockerell, 1901 |
| Sophia diffusa (A. Gray) Tidestr., 1935 |
| Sophia glabra Wooton & Standl., 1913 |
| Sophia halictorum Cockerell, 1898 |
| Sophia millefolia Rydb., 1905 |
| Sophia myriophylla Rydb., 1901 |
| Sophia obtusa Greene, 1904 |
| Sophia ochroleuca Wooton, 1898 |
| Sophia pinnata (Walter) Howell, 1897 |
| Sphaerocardamum S. Schauer, 1847 |
| Sphaerocardamum compressum (Rollins) Rollins, 1984 |
| Sphaerocardamum divaricatum (Rollins) Rollins, 1984 |
| Sphaerocardamum fruticulosum (Rollins) Rollins, 1984 |