| Matelea sagittifolia (A. Gray) Woodson ex Shinners, 1964 |
| Matelea schaffneri (A. Gray ex Hemsl.) Woodson, 1941 |
| Matelea serpens Woodson, 1944 |
| Matelea standleyana Woodson, 1941 |
| Matelea stenosepala Lundell, 1942 |
| Matelea suberifera (B.L. Rob.) W.D. Stevens, 1983 |
| Matelea sugillata W.D. Stevens, 2000 |
| Matelea tezcatlipocantha E.B.Cortez, Lozada-Pérez & L.O. Alvarado, 2018 |
| Matelea tigrinus Woodson, 1941 |
| Matelea tlilxochitli E. Cortez, Lozada-Pérez & L.O. Alvarado, 2018 |
| Matelea trachyantha (Greenm.) W.D. Stevens, 1983 |
| Matelea tristiflora (Standl. Woodson, 1941 |
| Matelea tuberosa (B.L. Rob.) Woodson, 1941 |
| Matelea tuerckheimii (Donn. Sm.) Woodson, 1941 |
| Matelea umbellata (Brandegee) Woodson, 1941 |
| Matelea vailiana Woodson, 1941 |
| Matelea velutina (Schltdl.) Woodson, 1941 |
| Matelea velutinoides W.D. Stevens, 2005 |
| Matelea wootonii (Vail) Woodson, 1941 |
| Matelea yucatanensis (Standl.) Woodson, 1941 |