| Sigela Hulst, 1896 |
| Sosxetra Walker, 1862 |
| Sosxetra grata Walker, 1862 |
| Sotigena Druce, 1890 |
| Sotigena notodontoides Druce, 1890 |
| Sphaeromachia Grote, 1867 |
| Sphaeromachia cubana (Herrich-Schäffer, 1866) |
| Sphaeromachia gaumeri (Druce, 1884) |
| Sphecosoma Butler, 1876 |
| Spilosoma Curtis, 1825 |
| Spilosoma dilecta Boisduval, 1870 |
| Spilosoma pelopea (Druce, 1897) |
| Spilosoma virginica (Fabricius, 1798) |
| Stenucha Hampson, 1901 |
| Stenucha dolens (Druce, 1897) |
| Sychesia Möschler, 1878 |
| Sychesia dryas (Cramer, 1775) |
| Symphlebia Felder, 1874 |
| Symphlebia alinda (Dyar, 1909) |
| Symphlebia herbosa (Schaus, 1910) |