| Piper sempervirens (Trel.) Lundell, 1937 |
| Piper sibunense Trel., 1936 |
| Piper silvivagum C. DC., 1899 |
| Piper smilacifolium Kunth, 1816 |
| Piper stevensonii Trel. ex Standl., 1936 |
| Piper stillans Trel. & Standl., 1952 |
| Piper stipulaceum Opiz, 1828 |
| Piper stipulare A.C. Sm., 1943 |
| Piper subaequilaterum Trel., 1940 |
| Piper subampollosum Callejas, 2020 |
| Piper subcitrifolium C. DC., 1920 |
| Piper subeburneum Trel. & Standl., 1952 |
| Piper sublineatum Kuntze, 1891 |
| Piper subsessilifolium C. DC., 1891 |
| Piper tacanaense Callejas, 2020 |
| Piper tacticanum Trel. & Standl., 1952 |
| Piper teapense C. DC., 1869 |
| Piper tecutlanum Trel. & Standl., 1952 |
| Piper telanum Trel., 1931 |
| Piper temiscoense Trel. ex Callejas, 2020 |