| Psilocybe schultesii Guzmán & S. H. Pollock, 1979 |
| Psilocybe singeri Guzmán, 1979 |
| Psilocybe singularis Guzmán, Escalona & J. Q. Jacobs, 2004 |
| Psilocybe spadicea P. Kumm., 1871 |
| Psilocybe subcubensis Guzmán, 1978 |
| Psilocybe subpsilocybioides Guzmán, Lodge & Cantrell, 2003 |
| Psilocybe subtropicalis Guzmán, 1995 |
| Psilocybe subyungensis Guzmán, 1978 |
| Psilocybe subzapotecorum Guzmán, 2000 |
| Psilocybe teofiloi Guzmán, J. Q. Jacobs & Ram.-Guill., 2005 |
| Psilocybe tuxtlensis Guzmán, 1983 |
| Psilocybe uxpanapensis Guzmán, 1979 |
| Psilocybe verae-crucis Guzmán & Pérez Ortiz, 1978 |
| Psilocybe villarrealiae Guzmán, 1998 |
| Psilocybe wassoniorum Guzmán & S. H. Pollock, 1979 |
| Psilocybe weldenii Guzmán, 1979 |
| Psilocybe xalapensis Guzmán & A. López, 1979 |
| Psilocybe yungensis Singer & A. H. Sm., 1958 |
| Psilocybe zapotecorum R. Heim, 1957 |
| Psilocybe zoncuantlensis Guzmán & Ram.-Guill., 1999 |