| Desmodium sonorae A. Gray, 1853 |
| Desmodium spicatum Rehder, 1922 |
| Desmodium spirale (Sw.) DC., 1825 |
| Desmodium spirale var. annuum (A. Gray) B.L. Rob. & Greenm., 1894 |
| Desmodium spirale var. bigelovii (A. Gray) B.L. Rob. & Greenm., 1894 |
| Desmodium spirale var. transversum B.L. Rob. & Greenm., 1894 |
| Desmodium strobilaceum Schltdl., 1838 |
| Desmodium subrosum G.L. Nesom, 1994 |
| Desmodium subsessile B.L. Rob. & Seaton, 1893 |
| Desmodium subsessile Schltdl., 1838 |
| Desmodium subspicatum S. Watson, 1891 |
| Desmodium subtile Hemsl., 1880 |
| Desmodium sumichrastii (Schindl.) Standl., 1936 |
| Desmodium supinum (Sw.) DC., 1825 |
| Desmodium sylvaticum Benth., 1843 |
| Desmodium sylvicola Brandegee, 1922 |
| Desmodium tastense Brandegee, 1903 |
| Desmodium tenuiculum DC., 1825 |
| Desmodium tiliifolium D. Don, 1825 |
| Desmodium tortuosum (Sw.) DC., 1825 |