| Desmodium robinsonii (Standl.) Standl., 1929 |
| Desmodium rosei B.G. Schub., 1940 |
| Desmodium rubricaule (Rose & Painter) Riley, 1923 |
| Desmodium saxatile (Morton) B.G. Schub. & McVaugh, 1987 |
| Desmodium scalare B.G. Schub. & McVaugh, 1987 |
| Desmodium schindleri B.G. Schub., 1941 |
| Desmodium schusteri (Schindl.) Standl., 1936 |
| Desmodium scopulorum S. Watson, 1889 |
| Desmodium scorpiurus (Sw.) Poir., 1819 |
| Desmodium scutatum Hemsl., 1880 |
| Desmodium seatonii Greenm., 1903 |
| Desmodium sericeum (Schindl.) Standl., 1937 |
| Desmodium sericocarpum Hemsl., 1880 |
| Desmodium sericophyllum Schltdl., 1838 |
| Desmodium sericophyllum var. strobilaceum (Schltdl.) N. Zamora, 2000 |
| Desmodium serotinum (Willd.) DC., 1825 |
| Desmodium sessilifolium Torr. & A. Gray, 1840 |
| Desmodium skinneri Benth. ex Hemsl., 1880 |
| Desmodium skinneri var. curtum (M.E. Jones) B.G. Schub. & McVaugh, 1987 |
| Desmodium skinneri var. flavovirens B.G. Schub. & McVaugh, 1987 |