| Piper cordoncillo var. apazoteanum Trel., 1929 |
| Piper cordovanum C. DC., 1869 |
| Piper cordulatum C. DC., 1866 |
| Piper corrugatum Kuntze, 1891 |
| Piper crassinervium Kunth, 1816 |
| Piper cubilquitzianum C. DC., 1920 |
| Piper curtirachis W.C. Burger, 1971 |
| Piper curtispicum C. DC., 1897 |
| Piper curvatipes Trel., 1937 |
| Piper cuspidispicum Trel., 1929 |
| Piper darienense C. DC., 1869 |
| Piper davidsonii Yunck., 1950 |
| Piper decipiens (Miq.) C. DC., 1869 |
| Piper decurrens C. DC., 1866 |
| Piper deductum Trel., 1937 |
| Piper dendroamans Trel. ex Callejas, 2020 |
| Piper descourtilsianum C. DC., 1869 |
| Piper diandrum C. DC., 1872 |
| Piper dilatatum Rich., 1792 |
| Piper discolor Trel., 1937 |