| Epidendrum deamii Schltr., 1918 |
| Epidendrum delicatissimum Rchb. f., 1877 |
| Epidendrum dickinsonianum Withner, 1970 |
| Epidendrum difforme Jacq., 1760 |
| Epidendrum diffusum Sw., 1788 |
| Epidendrum diffusum var. depauperatum Cogn., 1898 |
| Epidendrum diguetii Ames, 1923 |
| Epidendrum diotum Lindl., 1843 |
| Epidendrum discolor A. Rich. & Galeotti, 1845 |
| Epidendrum distantiflorum A. Rich. & Galeotti, 1845 |
| Epidendrum dixiorum Hágsater, 1993 |
| Epidendrum doeringii (Hoehne) A.D. Hawkes, 1957 |
| Epidendrum dorsocarinatum Hágsater, 1984 |
| Epidendrum dressleri Hágsater, 1987 |
| Epidendrum dunnii A.D. Hawkes, 1952 |
| Epidendrum durangense Hágsater & Holman, 1984 |
| Epidendrum eduardo-perezii Hágsater & E. Santiago, 2013 |
| Epidendrum elegans (Knowles & Westc.) Rchb. f., 1862 |
| Epidendrum ensatum A. Rich. & Galeotti, 1845 |
| Epidendrum ensicaulon A. Rich. & Galeotti, 1845 |