| Peromyscus pseudocrinitus Burt, 1932 |
| Peromyscus purepechus Léon-Tapia, Fernández, Rico, Cervantes, & Espinosa de los Monteros, 2020 |
| Peromyscus rowleyi J. A. Allen, 1893 |
| Peromyscus rowleyi subsp. pinalis G. S. Miller, 1893 |
| Peromyscus sagax Elliot, 1903 |
| Peromyscus schmidlyi Bradley, Carroll, Haynie, Muñiz Martínez, Hamilton & Kilpatrick, 2004 |
| Peromyscus sejugis Burt, 1932 |
| Peromyscus simulatus Osgood, 1904 |
| Peromyscus simulus Osgood, 1904 |
| Peromyscus slevini Mailliard, 1924 |
| Peromyscus sloeops Goodwin, 1955 |
| Peromyscus sonoriensis (LeConte, 1853) |
| Peromyscus sonoriensis subsp. blandus Osgood, 1904 |
| Peromyscus sonoriensis subsp. fulvus Osgood, 1904 |
| Peromyscus spicilegus J. A. Allen, 1897 |
| Peromyscus spicilegus subsp. evides Osgood, 1904 |
| Peromyscus spicilegus subsp. simulus Osgood, 1904 |
| Peromyscus spicilegus subsp. spicilegus J. A. Allen, 1897 |
| Peromyscus stephani Townsend, 1912 |
| Peromyscus stephensi Mearns, 1897 |