| Handleyomys rhabdops (Merriam, 1901) |
| Handleyomys rhabdops subsp. angusticeps (Merriam, 1901) |
| Handleyomys rostratus (Merriam, 1901) |
| Handleyomys rostratus subsp. carrorum (Lawrence, 1947) |
| Handleyomys rostratus subsp. megadon (Merriam, 1901) |
| Handleyomys rostratus subsp. rostratus (Merriam, 1901) |
| Handleyomys rostratus subsp. yucatanensis (Merriam, 1901) |
| Handleyomys saturatior (Merriam, 1901) |
| Handleyomys saturatior subsp. hylocetes (Merriam, 1901) |
| Handleyomys saturatior subsp. saturatior (Merriam, 1901) |
| Hesperomys Waterhouse, 1839 |
| Hesperomys affinis J. A. Allen, 1891 |
| Hesperomys alfaroi J. A. Allen, 1891 |
| Hesperomys anthonyi Merriam, 1887 |
| Hesperomys aztecus Saussure, 1860 |
| Hesperomys boylii Baird, 1855 |
| Hesperomys couesi Alston, 1877 |
| Hesperomys crinitus Merriam, 1891 |
| Hesperomys eremicus Baird, 1858 |
| Hesperomys fulvescens Saussure, 1860 |